The impact of tillage system, rotation sequence and foliar fungicides on diseases and seed yield and quality of wheat, barley, pea, canola and flax was determined in the second cycle of three, 4-year rotations from 1998 to 2001 on a Black Chernozem (Udic Boroll) at Melfort, Saskatchewan, Canada. The objective of the study was to evaluate the impact of reduced-tillage production systems, broadleaf cropping intensity and fungicide use on cereal, oilseed and pulse crops in northeastern Saskatchewan, a sub-humid region of the northern Great Plains. A split-split plot design was used with three tillage systems (conventional, minimum and no-till) as main plots, three rotations of increasing broadleaf crop intensity (1. canola-wheat-barley-barley; 2. canola-barley-pea-wheat; and 3. canola-pea-flax-barley) as sub-plots, and fungicide treatments (treated or untreated) as sub-sub-plots. Fungicides appropriate for the diseases of concern were applied at recommended crop development stages and application rates, followed by assessment of diseases. Tillage system had little impact on diseases of any crop, although seed yield was usually greater under no-till for most crops under dry conditions. Rotation was not a major factor in disease severity of most of the crops, except barley in the rotation where it was grown for two consecutive years. Under dry conditions, barley yield was reduced when it followed flax compared with other crops, most likely due to less available soil moisture after flax. Fungicide application had the greatest impact on disease control and seed yield increase, although results varied among crops and years. In conclusion, the findings indicate that tillage system had little effect on disease severity, rotation contributed to greater disease severity only when a crop was grown intensively, such as on its own stubble, and fungicide application had variable effects on both disease control and seed yield.