Field experiments were carried out in 2005-2007 in the Experimental Station at Winna Gora, belonging to the Institute of Plant Protection - National Research Institute in Poznan. The aim of this study was to compare the efficacy of the herbicide mixtures tritosulfuron+dicamba (Mocarz 75 WG) in spring wheat variety Bryza, spring barley var. Antek and oat var. Cwa, sown separately and in cereal mixtures. Mocarz 75 WG herbicide was applied at a dose of 0.2 kg.ha -1 in the 3-5 leaf stage of cereals, using knapsack sprayer Gloria. Analysis of weed infestation of cereals were made by volume-weight assessment, twice during the growing season (3-4 weeks after herbicide application and 7-8 weeks after application). The efficacy of the herbicide in the cereal mixtures was compared with its effectiveness in the individual species. Analyses indicated that the barley-oat mixtures were the slightest and wheat-oat mixtures were the most infested by weeds. It was confirmed that a mixture of wheat and barley, wheat and oat and barley with oat reduced the influence of weed infestation. The higher efficacy of the mixture tritosulfuron+dicamba in cereal mixtures compared to the individual components was also indicated. Grain yields of cereals in mixtures with wheat as a component were significantly higher than in pure stands of wheat, while the yields of barley and oat mixture yielded higher than the two species sown alone.