Field studies were conducted from 1996 through 2006 in southeastern Kansas to evaluate the influence of previous crop [corn, Zea mays L.; grain sorghum, Sorghum bicolor (L.); and soybean, Glycine max (L.) Merr.] and tillage system (conventional versus no-till) on grain yield of hard red winter wheat ( Triticum aestivum L.) and double-crop soybean in a 2-year rotation. On average, wheat yield was greater following corn or soybean than following grain sorghum. Yield of double-crop soybean averaged 20% greater when wheat followed corn or grain sorghum than when wheat followed full-season soybean. Tillage system influenced grain yield of double-crop soybean more than it influenced wheat yield. Double-crop soybean yield often was greater for continuous no-till than for conventional or one-time no-till per cropping cycle. Soil analyses at the end of the study showed that total C and total N were greater for no-till than for conventional in the 0- to 3-inch depth, but total C and total N were greater for conventional than no-till in the 3- to 6-inch depth. In the multi-cropping systems of the eastern Great Plains, both crop rotation and tillage system can significantly influence grain yield and selected soil properties.