In the eastern Great Plains, winter wheat ( Triticum aestivum L.) is often rotated with other crops to diversify cropping systems. In these multicropping systems, wheat typically is planted with conservation tillage methods, but previous crop residues influence fertilizer N management. This field study was conducted from 1992 through 2001 in southeastern Kansas on a Parsons silt loam soil (fine, mixed, thermic, Mollic Albaqualf). The objectives were to determine effects and interactions of previous crop {grain sorghum [ Sorghum bicolor (L.) Moench] and soybean [ Glycine max (L.) Merr.]}, tillage system [reduced tillage (RT) and no-tillage (NT)], N rate (67 and 134 kg ha -1), and preplant placement (surface-broadcast and subsurface-knife) of urea ammonium nitrate solution (UAN, 280 g kg -1) on wheat grain yield, yield components, and plant N uptake in a 2-yr cropping rotation. Wheat yields averaged 3.39 Mg ha -1 following soybean compared with 2.90 Mg ha -1 following grain sorghum. Tillage effects on grain yield were smaller than other treatment factors, averaging 3.23 Mg ha -1 for RT and 3.06 Mg ha -1 for NT. Grain yields were greatest in all cropping systems for the high-N-rate subsurface-knife treatment. Plant N uptake responses indicated that grain yield differences were primarily related to greater immobilization of both fertilizer and soil N following grain sorghum, compared with soybean, and to better utilization of subsurface-knifed N than surface-broadcast N. Results indicate that wheat yield potential is more strongly influenced by previous crop, fertilizer N rate, and N placement method than tillage system.