The agronomic and economic performance of five alternative crops was assessed in comparison to the no-till wheat-soyabean double-cropping system prevalent in the southern Corn Belt of the USA. A field site was established in 1992 at the University of Missouri-Columbia and two further sites in Missouri were added in 1993. Amaranth, buckwheat, sunflower, and pearl millet were planted after the harvest of canola [rape] or wheat, or after fallow. Alternative double-crop grain yield, production costs, and net returns were compared with those of double-crop soyabean. Wheat yielded more than canola. Sunflower grain yields did not differ significantly after winter-crop treatments at any site. Yields of amaranth, buckwheat, soyabean, and pearl millet differed after winter crops at some sites. At three study yield levels, net returns were positive and greatest for double-crop wheat-amaranth, canola-amaranth, wheat-sunflower, and canola-sunflower systems. All double-crop systems except canola-pearl millet had positive net returns at median study yield levels. Low or negative net returns resulted from the combination of low yield and low price for some double crops. Canola was shown to be an economically feasible alternative to wheat in a double-cropping system for central and southern Missouri. Buckwheat and sunflower were shown to be agronomically and economically competitive alternatives to soyabean following either canola or winter wheat, with buckwheat most valuable in late-season planting conditions.