Field experiment were conducted to investigate the effects of flue-cured tobacco and sweet potato intercropping on quality and economic benefits of flue-cured tobacco leaves. The results were as follow: compared with monocropping, flue-cured tobacco intercropping with sweet potato the yield of flue-cured tobacco leaves were increased 117.99 kg per hectare and increased by 4.26%, the proportion of superior and middle tobacco leaves were increased by 3.24%-14.53% and 4.54%-12.44%, respectively, meanwhile the proportion of low-grade leaves was decreased by 10.08% and 25.28%. The average price of flue-cured tobacco leaves were increased by 0.50-0.53 yuan per kilogram and the rise range was between 4.38%-4.56%. In addition, the sweet potato tube and bushrope yield were increased by 3226-7856 and 19 351-36 520 kilogram per hectare, respectively, income respectively increased by 3871-9427 and 5805-10956 yuan per hectare, the total economic income were increased 16 368-18 133 yuan per hectare and increased by 48.82%-56.40%, the different of producing value is significant at 5% level.