Fluctuations in dryland cotton yield in the Tennessee Valley region of northern Alabama are common and are usually related to irregular drought periods during the growing season. Subsurface drip irrigation (SDI) has gained popularity as a water delivery system for small, irregular-shaped cotton fields. A seven-year study was conducted with the objective to determine the response of seed cotton yield to SDI tape orientation relative to crop row direction and different irrigation rates under dryland conditions of the Tennessee Valley. Seven treatments were tested in a randomized incomplete block design which consisted of three irrigation treatments (33%, 66%, and 99% pan evaporation), two SDI tape orientations (parallel and perpendicular), and a dryland control. All SDI treatments produced yields significantly higher than non-irrigated, dryland cotton in four out of seven years. Maximum yield was obtained at a median pan evaporation water replacement value of 74%. No statistical differences were observed between SDI tape orientations on seed cotton yield in all years except in 1999 when parallel out yielded perpendicular at lower irrigation rates. Results confirm the long-term efficacy of supplemental irrigation to increase seed cotton yield irrespective of SDI tape placement during sporadic periods of drought. These results are applicable only for fields with the same soil type or with similar water movement characteristics.