Comparative studies of soil quality and energy use in two- and three-crop rotations in irrigated cotton ( Gossypium hirsutum L.) based cropping systems under varying stubble management practices in Australian Vertosols are sparse. Our primary objective was to quantify selected soil quality indices (salinity, sodicity, exchangeable cations, nitrate-N, pH), crop yields, and greenhouse gas emissions in four irrigated cotton-based cropping systems sown on permanent beds in a Vertosol with subsoil sodicity near Narrabri in north-western New South Wales. A secondary objective was to evaluate the efficacy of sowing vetch in rotation with cotton over a long period on the incidence of black root-rot in cotton seedlings. Results: presented in this report pertain to the period June 2005-May 2011. The experimental treatments were: cotton-cotton; cotton-vetch ( Vicia benghalensis L.); cotton-wheat ( Triticum aestivum L.), where wheat stubble was incorporated; and cotton-wheat-vetch, where wheat stubble was retained as in-situ mulch. Vetch was terminated during or just before flowering by a combination of mowing and contact herbicides, and the residues were retained as in-situ mulch. Soil pH, electrical conductivity (EC 1:5), Cl -, NO 3--N, exchangeable cations, exchangeable sodium percentage (ESP), electrochemical stability index (=EC 1:5/ESP), and EC 1:5/ESC (exchangeable sodium concentration) were evaluated in samples taken from the 0-1.2 m depth before sowing cotton during late September or early October of each year. Incidence of black root-rot was assessed 6 weeks after sowing cotton. Compared with sowing cotton every year, including wheat in cotton-based cropping systems improved cotton yield and reduced soil quality decline, emissions of carbon dioxide equivalents (CO 2-e) per unit area, and CO 2-e emissions per unit of cotton yield. Including vetch in the rotation was of negligible benefit in terms of yield and CO2-e emissions per unit of yield. The rate of soil quality decline was unaffected by including vetch in a cotton-wheat rotation but was accelerated when included in a cotton-cotton sequence. Among all cropping systems, soil quality was best with cotton-wheat and cotton-wheat-vetch but poorest with cotton-vetch. Although CO2-e emissions associated with growing 1ha of cotton could be reduced by 9% by growing vetch because of substituting fixed atmospheric N for N fertiliser derived from fossil fuels, this advantage was partly negated by the emissions from farming operations associated with growing a vetch crop. Relative to a two-crop rotation (one cotton-one rotation crop), negligible benefits in terms of yield, soil quality, greenhouse gas emissions, and black root-rot control accrued from a three-crop rotation (one cotton-two rotation crops). Incidence of black root-rot increased as the number of cotton crops sown increased. In addition to the cropping systems, soil quality indices and yield were significantly influenced by irrigation water quality and climate.