The field experiment was conducted at College of Agriculture Farm, Raichur on medium black soil during kharif, 2009 to study the weed management in Bt cotton ( Gossypium hirsutum L.) under irrigation. The results revealed that among the weed management treatments, weed free check recorded significantly higher uptake of nutrients (111.01, 31.21 and 129.11 NPK kg ha -1) and was followed by pendimethalin 38.7 CS (PRE)+quizalofop ethyl 5 EC (POE)+IC and HW at 60 DAS (T 12). With regards to yield and economics, pendimethalin 38.7 CS (PRE)+quizalofop ethyl 5 EC (POE)+IC and HW at 60 DAS (T 12) gave significantly higher seed cotton yield (14.06 q ha -1) and higher gross returns (Rs 35,150 ha -1), net returns (Rs 11,857 ha -1) and BC ratio (1.51).