The field experiment for cotton crop (Gossypium hirsutum L.) was conducted at the Zhongjie Farm, Huanghua city of Hebei province in the coastal salinity-affected areas in North China Plain, to determine the effects of an alternative of irrigation water sources/methods and agronomic practices on seedling emergence and yields of cotton, soil water-salt distributions, and soil pH changes during cotton growth stages. The experiment was setup using split-plot design with two water sources as main treatments (well water/desalinized sea-ice water); two irrigation methods (+PAM (Polyacrylamide)/-PAM); and four fertilization modes: check (CK), mineral fertilizer (F), mineral + organic fertilizer (FM), and mineral fertilizer + gypsum (FG). Using desalinized sea-ice water irrigation showed the same effects on top-soil salt leaching and desalinization as using well water did. There was no significant difference in seedling emergence and cotton yields between two irrigation water sources for cotton irrigation. Using PAM-treated irrigation, the 10-cm top-soil salinity significantly decreased to about 2.3-3.9 g kg(-1) from 4.6 to 8.6 g kg(-1) (PAM untreated). The PAM-treated irrigation increased seedling emergence by about 13, 29 and 36% and yields by about 50, 49, and 70%, with F, FM, and FG, respectively, as compared with CK. PAM-treated irrigation, either using well water or desalinized sea ice, especially in combination with gypsum-fertilization, shows the best practice for both seedling emergence and cotton yields. In conclusion, the desalinized sea-ice water used as an alternative water source, integrated with better agronomic practices of soil water-salt management could be acceptable for cotton irrigation in the coastal saline areas.