Objective: In order to discuss the effect of gentle salt-water irrigation on yield of cotton and its quality, a field experiment was conducted at the national irrigation experiment station of Kuerle city in 2008. The research has studied the effect of gentle salt-water alternated with fresh-water irrigation on cotton yield and yield component. Method: This experiment was carried out to use different gentle salt-water rate and different fresh-water rate to find out an appropriate amount of irrigation. Result: The results showed that the cotton yield and its fiber quality can be improved by gentle salt-water alternated with fresh-water irrigation of 3 g/L of mineralized degree in the south Xinjiang. Salt which was carried into soil could be rush into a deep layer of the soil profile by fresh-water irrigation and winter irrigation, and the total salinity of the soil generally kept its balance. Conclusion: By analyzing the tested index of every cotton growth stage, it was found out when gentle salt-water irrigation rate was 2 250 m 3/hm 2 and the fresh-water irrigation rate was 1 500 m 3/hm 2, cotton yield was higher.