The promising allelopathic potential of sorghum [Sorghum bicolor L. (Moench)] opens a fruitful area of research to exploit this phenomenon in weed control and regulation of nutrients cycle. The data suggests that sorghum allelopathy can be exploited in different cropping practices [cover crop, smother crop, companion crop. mixing crop and smother crop to control weeds and inhibition of nitrification] and, application of its water extracts in fields controls the weeds and enhances the crops productivity. The herbicidal and allelopathic properties of sorgoleone. a compound isolated from root exudates of sorghum and other allelochemicals in sorghum deserve further work to identify the enzymes responsible for the biosynthesis oil these compounds and the genes encoding them. Besides there is need to use genetic engineering to manipulate the identified genes in sorghum or in other crops to enhance their ability to suppress the weeds, This review addresses the research on the role of allelopathic potential in different cropping systems and the approaches developed in weeds management.