Studies on irrigation scheduling for soybean have demonstrated that avoiding irrigation during the vegetative growth stages could result in yields as high as those obtained if the crop was fully irrigated during the entire growing season. This could ultimately also lead to an improvement of the irrigation water use efficiency. The objective of this study was to determine the effect of different irrigation regimes (IRs) on growth and yield of four soybean genotypes and to determine their irrigation water use efficiency. A field experiment consisting of three IR using a lateral move sprinkler system and four soybean genotypes was conducted at the Bledsoe Research Farm of The University of Georgia, USA. The irrigation treatments consisted of full season irrigated (FSI), start irrigation at flowering (SIF), and rainfed (RFD); the soybean genotypes represented maturity groups (MGs) V, VI, VII, and VIII. A completely randomized block design in a split-plot array with four replicates was used with IR as the main treatment and the soybean MGs as the sub-treatment. Weather variables and soil moisture were recorded with an automatic weather station located nearby, while rainfall and irrigation amounts were recorded with rain gauges located in the experimental field. Samplings for growth analysis of the plant and its components as well as leaf area index (LAI) and canopy height were obtained every 12 days. The irrigation water use efficiency ( IWUE) or ratio of the difference between irrigated and rainfed yield to the amount of irrigation water applied was estimated. The results showed significant differences ( P