An experiment was conducted to compare the production potential and economic feasibility of various crop combinations, i.e. cotton (cv. Anjali 561) intercropped with cowpea, urd bean and dhaincha, and soyabean (cv. JS 335) intercropped with maize, sorghum and pigeon pea, under rainfed farming conditions in Nagpur, Maharashtra, India, during 2002-04. The soils of the area are 22-24 cm deep (underlain by murrum/saprolite up to 40-45 cm), well-drained (Lithic Ustorthents) and occur on 1-3 and 3-5% slope. Cotton intercropping comprised row to row at 90 cm and plant to plant at 45 cm, while soyabean intercropping comprised 2 rows of main and 2 rows of intercrop at 45 cm. Irrespective of the slope, the highest yield of cotton was recorded under cotton + cowpea cropping system; however, the highest net return was observed under cotton + cowpea cropping system. For soyabeans, the highest yield was recorded under sole soyabean crop in both soil slopes. Among the intercropping systems, soyabean + pigeon pea had the highest yield followed by sorghum under both slopes during 2002-03. In 2003-04, soyabean + sorghum gave the highest soyabean equivalent yield in both soils followed by soyabean + pigeon pea. Comparative data on gross return, net return, average net profit and land equivalent ratio for both cotton and soyabean cropping systems are also presented.