Experiments were conducted in North Carolina during 2005, 2006, and 2007 to determine peanut and weed response when peanut was planted in strip tillage after desiccation of cereal rye, Italian ryegrass, oats, triticale, wheat, and native vegetation by glyphosate and paraquat before planting with three in-season herbicide programs. Control of common ragweed and yellow nutsedge did not differ among cover crop treatments when compared within a specific herbicide program. Applying dimethenamid or S-metolachlor plus diclosulam PRE followed by imazapic POST was more effective than a chloroacetamide herbicide PRE followed by acifluorfen, bentazon, and paraquat POST. Incidence of spotted wilt in peanut (caused by a Tospovirus) did not differ when comparing cover crop treatments, regardless of herbicide program. Peanut yield increased in all 3 yr when herbicides were applied POST, compared with clethodim only. Peanut yield was not affected by cover crop treatment. Response to cover crop treatments was comparable, suggesting that growers can select cereal rye, Italian ryegrass, oats, or triticale as an alternative to wheat as a cover crop in peanut systems without experiencing differences associated with in-season weed management.