During the period 2006-2008 in the experimental field of the Experimental station of soybean - Pavlikeni is displayed field trial in non-irrigated conditions for establishing the efficacy and selectivity of the herbicide Diflufenikan - 500 g/l (Pelican 50 KS) in soybean agrocenosis background in natural mixed type weediness. Results obtained may be generalized in the following more important conclusions: Herbicides Diflufenikan - 500 g/l (Pelican 50SC) has relatively high selectivity (EWRS 2-3 ball) and is suitable for treatment of soybean crops after germination before sowing at a dose of culture 125 ml/ha. Herbicide effectiveness Diflufenikan - 500 g/l (Pelican 50 KS) varies from 73 to 89% on annual dicotyledonous weeds ( S. nigrum; Amaranthus spp.). Less herbicide effect (from 25 to 50%) is established under Ch. album and the least (from 8 to 52%) in the group of weeds annual Monocotyledon ( Setaria spp., Eh. crus-galli). The increase in grain yield of soybean varies from 11.3 to 106.0% compared to the control variant (control - zero) and is in direct relation to the effect achieved in the fight against weeds.