Studies that utilized rotation crops for management of root-knot nematodes in the southeastern United States were examined to evaluate the overall performance of rotation crops. In general, nematode-susceptible crops that followed effective rotation crops produced yields and supported nematode numbers similar to those obtained on crops treated with most standard nematicides. Fumigation with methyl bromide was an exception, and resulted in low nematode numbers up to the end of the susceptible target crop, whereas nematode numbers recovered following rotation crops. Performance of rotation crops was similar to clean fallow in most studies, and there was little evidence that rotation crops could suppress nematode numbers below levels obtained after clean fallow. Large reductions in nematode numbers often were achieved following rotation crops. In sites with relatively low initial population levels before rotation crops were used, effective rotation crops sometimes maintained relatively low nematode numbers through the following susceptible target crop, and nematode recovery was not observed until the second year of the rotation sequences. Where practical, very long rotations such as bahiagrass pastures were often effective in preventing increase in nematode numbers on subsequent susceptible crops. Rehabilitation of heavily infested sites is difficult, could require several years of rotation crops, and the benefit gained may last only through one susceptible crop.