A field experiment was conducted for three consecutive years (2005-2007) at Parbhani to find out most productive and profitable cropping system. Among the different cropping systems, highest wheat [( Triticum aestivum L.) emend. Fiori & Paol] equivalent yield (19.9 t/ha) and net monetary returns (Rs 107.8*10 3/ha) were obtained from soybean [ Glycine max (L. Merr.)]-onion ( Allium capa L.) cropping system, followed by turmeric ( Curcuma domestica L.)+castor ( Ricinus communis L.) (WEY-14.0 t/ha, and NMR Rs 89.8*10 3/ha). The soybean-onion system also recorded maximum net monetary advantage per unit time (Rs 573/ha/day), employment (374 mandays) and water use efficiency (221 kg/ha-cm), followed by turmeric+castor intercropping system. The highest nutrient uptake was recorded in sorghum [ Sorghum bicolor (L.) Moench]-wheat followed by maize ( Zea mays L.)+cow-pea ( Vigna sinensis L.)-wheat and maize-wheat cropping systems. The highest soil nutrient status was observed in cotton ( Gossypium sp.)-summer groundnut ( Arachis hypogaea L.) followed by soybean-onion cropping systems.