The present investigation is aimed at studying the relative economics of soybean based cropping systems against cotton mono crop in Gottipadu village of Prattipadu mandal in Guntur district of Andhra Pradesh. Regression analysis of soybean. Bengalgram revealed that, all the variables contributed positively but non-significant except plant protection chemicals. Regression analysis of soybean+redgram (inter crop) cropping system revealed that area and plant protection chemicals made positive and significant contribution and machine labour made negative and significant contribution towards the gross returns. Regression analysis of soybean-jowar cropping system revealed that plant protection chemicals made a significant and positive contribution whereas fertilisers made a significant and negative contribution towards gross returns. Regression analysis of cotton revealed that area, seed, manual labour and machine labour made a significant and positive contribution towards the gross returns.