The objective of this work was to compare the potential of the irrigated wheat under no tillage and conventional cropping systems, as well as to evaluate the performance of fifteen wheat cultivars in the two cropping systems, in succession to soybean crop, in the South of Minas Gerais. The experiment was carried out in the Federal University of Lavras (UFLA), in Lavras, MG, in the years of 2006/07 and 2007/08, in a split-block-designed scheme in a randomized complete block design, with three replications. The cropping systems (conventional and no-tillage) were installed in the rows and, in the columns, the fifteen wheat cultivars were distributed. The wheat yield and others agronomic characteristics were evaluated. The no-tillage provided an average increase of 25% in the organic matter levels in the topsoil layer in relation to previous levels and to conventional cropping system. The cultivars tested, independent of the agricultural year, significantly altered the grain yields and the agronomic characteristics. The high yield presented by the cultivars evaluated in this study indicates the high potential of the irrigated wheat cropped in succession to soybean crops, under similar climatic and soil conditions used in this study.