A field experiment was conducted on clay soil (Typic Haplusterts) of MAU, Parbhani during 2002-03 to study the effect of application of organic, inorganic and organic combined with inorganic nutrient sources on yield of various cropping systems, NPK uptake and balance in soil. Recommended dose of fertilizers and combined application of glyricidia @1.5 t ha -1+25% RDF increased grain yield and N, P, K uptake. The highest total grain yield (2335 kg ha -1) was recorded by RDF fallowed by glyricidia @1.5 t ha -1+25% RDF (2213 kg ha -1) and it was at par with each other. The cropping systems sorghum+pigeonpea recorded highest yield (2438 kg ha -1). The maximum N, P and K uptake (142.16, 23.92 and 63.71 kg ha -1 respectively) was recorded with the soybean+pigeonpea cropping system. There, was more buildup of available N, P and K in soil with soybean+pigeonpea cropping system with FYM followed by glyricidia.