Recent soil and crop management technologies have potential for mitigating greenhouse gas emissions; however, these management strategies must be profitable if they are to be adopted by producers. The economic feasibility of reducing net greenhouse gas emissions in irrigated cropping systems was evaluated for 5 yr on a Fort Collins clay loam soil (a fine-loamy, mixed, superactive, mesic Aridic Haplustalf). Cropping systems included conventional tillage continuous corn (Zea mays L.) (CT-CC), no-till continuous corn (NT-CC), and no-till corn-bean (NT-CB) including 1 yr soybean [Glycine max (L.) Merr.] and 1 yr dry bean (Phaseolus vulgaris L.). The study included six N fertilization rates ranging from 0 to 246 kg ha-1. Results showed highest average net returns for NT-CB, exceeding net returns for NT-CC and CT-CC by US$182 and US$228 ha-1, respectively, at economically optimum N fertilizer rates. Net global warming potential (GWP) generally increased with increasing N fertilizer rate with the exception of NT-CC, where net GWP initially declined and then increased at higher N rates. Combining economic and net GWP measurements showed that producers have an economic incentive to switch from CT-CC to NT-CB, increasing annual average net returns by US$228 ha-1 while reducing annual net GWP by 929 kg CO2 equivalents ha-1. The greatest GWP reductions (1463 kg CO2 equivalents ha-1) could be achieved by switching from CT-CC to NT-CC while also increasing net returns, but the presence of a more profitable NT-CB alternative means NT-CC is unlikely to be chosen without additional economic incentives.