Management practices, such as irrigation, tillage, cropping system, and N fertilization, may influence soil greenhouse gas (GHG) emissions. We quantified the effects of irrigation, tillage, crop rotation, and N fertilization on soil CO2, N2O, and CH4 emissions from March to November, 2008 to 2011 in a Lihen sandy loam in western North Dakota. Treatments were two irrigation practices (irrigated and nonirrigated) and five cropping systems (conventional-tilled malt barley [Hordeum vulgaris L.] with N fertilizer [CT-N], conventional-tilled malt barley with no N fertilizer [CT-C], no-tilled malt barley pea [Pisum sativum L.] with N fertilizer [NT-PN], no-tilled malt barley with N fertilizer [NT-N], and no-tilled malt barley with no N fertilizer [NT-C]). The GHG fluxes varied with date of sampling and peaked immediately after precipitation, irrigation, and/or N fertilization events during increased soil temperature. Both CO2 and N2O fluxes were greater in CT-N under the irrigated condition, but CH4 uptake was greater in NT-PN under the nonirrigated condition than in other treatments. Although tillage and N fertilization increased CO2 and N2O fluxes by 8 to 30%, N fertilization and monocropping reduced CH, uptake by 39 to 40%. The NT-PN, regardless of irrigation, might mitigate GHG emissions by reducing CO2 and N2O emissions and increasing CH4 uptake relative to other treatments. To account for global warming potential for such a practice, information on productions associated with CO2 emissions along with N2O and CH4 fluxes is needed.