While crop rotation patterns can be complex with multiple crops rotated over several years, the most common rotation practice in the Central United States is biannual rotation between corn and soybeans. We analyzed the changes in crop rotation patterns from 2003 to 2010 using the Cropland Data Layer (CDL), which provides remotely sensed land cover layers for agricultural crops in the Central United States. The accuracy of the CDL was validated by comparing the total acreage for a state or county present in the CDL with the total planted crop acreage available from the National Agricultural Statistics Service. The data layers were combined into two time periods 2003-2006 and 2007-2010, and specific rotation patterns were determined for every location in the study area. The combinations resulted in unique sequences such as single, double, triple and quadruple, the latter of which is equivalent to the same crop class present all four years at a particular location. Corn and soybeans were analyzed to determine the amount of area used for production as well as the amount of change between unique crop rotation sequences. While the total area under production of major crops in the second half of our study period increased only slightly, the extent to which major crops (e.g., corn and soybeans) were grown in continuous cropping sequences increased significantly. For example, the amount of land impacted by corn in the first time period increased by only 2% in the second time period. However, the amount of corn grown in quadruple sequence doubled from the first half to the second half of our study period. We conclude that, although crop rotation patterns are very complex in this region, involving considerable amount of non-cropland, the footprint of major crops such as corn have moved toward monoculture cropping practices in the last decade.