The aim of the study is to analyze the effects of different fertilization of organic and inorganic fertilizers on soil organic carbon (SOC) sequestration and crop yields after a 22 years long-term field experiment. The crop yields and SOC were investigated from 1981 to 2003 in Dry-Land Farming Research Institute of Hebei Academy of Agricultural and Forestry Sciences, Hebei Province, China. The dominant cropping systems are winter wheat-summer corn rotation. There were totally sixteen treatments applied to both wheat and corn seasons: inorganic fertilizers as main plots and corn stalks as subplots and the main plots and subplots all have four levels. The results revealed: after 22 years, mixed application of inorganic fertilizers and crop residuals, the SOC and crop yields substantially increased. Higher fertilizer application rates resulted in greater crop yields improvement. In 2002-2003, wheat and corn for the highest fertilizer inputs had the highest yield level, 6400 kg ha-1 and 8600 kg ha-1, respectively. However, the SOC decreased as the excessive inorganic fertilizer input and increased with the rising application of corn stalks. The treatment of the second-highest inorganic fertilizer and the highest corn stalks had the highest SOC concentration (8.64 g C kg-1). Pearson correlation analysis shows that corn and winter wheat yields and the mineralization amount of SOC have significant correlation with SOC at p < 0.05 level.